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Researchers have developed an innovative method that allows old cells to be “restarted,” restoring their ability to divide, which in experiments with mice contributed to increased lifespan and improved physical and cognitive condition.
The basis of this method was the microRNA miR-302b, which, according to scientists, “is capable of reversing the process of cellular aging.” Injections of this molecule into aging mice reduced signs of aging, such as deterioration of physical functions and hair loss. As a result, the mice not only lived longer, but also maintained their activity and mental abilities. Despite the encouraging results, the question of the effectiveness of this therapy in humans remains open.
The miR-302b molecule is found in exosomes, “tiny vesicles secreted by embryonic stem cells” (hightech.fm). Experiments have shown that this molecule can repair cells that have stopped dividing, restoring them to normal function. Administering exosomes to mice significantly improved their physical condition, coordination, memory, and learning ability.
Importantly, the resumption of cell division was not accompanied by an increased risk of tumor development or other complications even two years after the start of therapy. This indicates the safety of the approach. As the authors note, the technology does not simply slow down aging, but partially “reverses it,” allowing cells to maintain genomic stability.
Despite the optimistic prospects, additional research is needed for the method to be clinically implemented. The scientists plan to expand the animal sample to confirm the safety of the therapy and develop methods for mass production of exosomes. These steps are critical for adapting the technology to medical needs.
The method using miR-302b opens up new horizons in the fight against aging, but its application requires caution and detailed study to ensure success in the treatment of human patients.
