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Researchers from the Netherlands have made a breakthrough in regenerative medicine by discovering the protein Hmga1, which could be the key to treating complications after a heart attack and significantly reducing the risk of developing heart failure.
In zebrafish, this protein promotes complete heart muscle regeneration in two months. Transferring its functions to mice allowed to achieve similar results: the affected areas of the heart muscle began to regenerate due to the activation of cell division and growth. As scientists from Hubrecht University note, “Hmga1 removes molecular obstacles on chromatin, clearing the way for gene activity.” This discovery helps to understand the mechanisms behind natural tissue regeneration.
Notably, the treatment in the mouse models acted selectively, activating repair processes only in damaged areas without side effects. According to study co-author Mara Bowman, “the recovery process took place only in the target area.” This makes Hmga1 a promising candidate for gene therapy in humans, in whom this gene is only active during embryonic development.
Successful adaptation of the discovery to human medicine would open up the possibility of halting complications after a heart attack, the leading cause of heart failure. The development of such treatments would have a significant impact on global medicine.
Additionally, when combined with innovative diagnostic technologies, such as chips for rapid detection of heart attacks through blood tests, these studies are shaping a new approach to preventing and treating cardiovascular disease.
The effects of a heart attack can be reversed appeared first on Curiosity.
